1. What is Feline Infectious Peritonitis (FIP)?
FIP is a fatal disease caused by a mutation of feline coronavirus (FCoV), primarily affecting kittens and immunocompromised cats.
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Key Characteristics:
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Common feline coronavirus (FCoV) is typically harmless in the intestines, but when mutated, it attacks systemic organs.
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Fatality Rate: Untreated FIP is nearly 100% fatal.
2. Two Forms of FIP & Symptoms
① Wet FIP (Effusive Form)
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Key Signs:
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Fluid accumulation in abdomen/chest (swollen belly or labored breathing)
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Persistent fever (>39.5°C/103.1°F)
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Jaundice (yellow gums/ears)
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Diagnosis: Positive Rivalta test on effusion fluid, PCR confirmation.
② Dry FIP (Non-Effusive Form)
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Key Signs:
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Eye inflammation (uveitis)
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Neurological symptoms (seizures, unsteady gait)
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Granulomas in organs (detected via ultrasound/biopsy)
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Diagnostic Challenges: Requires combined blood tests (e.g., hyperglobulinemia), imaging, and antibody titers.
3. The Treatment Revolution: How GS-441524 Works
① Mechanism
GS-441524 is a nucleoside analog that “mimics” viral RNA components to block viral replication.
② Treatment Protocol
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Duration: 84-day injections + 12-week observation (to prevent relapse)
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Success Rate: >85% with early intervention
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Side Effects: Mild injection site reactions or temporary appetite loss in some cats.
③ Treatment Options Comparison
| Method | Pros | Cons |
|---|---|---|
| Injections | Fast absorption, stable efficacy | Requires daily subcutaneous shots |
| Tablets | Stress-free administration | Must be given on empty stomach; higher cost |
4. Practical Advice for Pet Owners
① Early Detection: Seek immediate vet care if your cat shows persistent fever, abdominal swelling, or lethargy.
② Diagnostic Essentials:
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Required tests: CBC, blood chemistry (focus on A/G ratio), ultrasound
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Optional tests: PCR, Rivalta test
③ Treatment Tips: -
Wrap cats in a towel during injections; use treats for distraction
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Track daily temperature and appetite changes
5. Debunking Common Myths
❌ “FIP is contagious to other cats”
✅ Truth: Only non-mutated FCoV is contagious; FIP-causing mutated virus cannot spread cat-to-cat.
❌ “Supplements can cure FIP”
✅ Truth: Only antivirals like GS-441524 are curative—supplements provide supportive care only.
Conclusion
FIP is no longer a death sentence! With science-backed treatment and dedicated care, your cat can fully recover. For assistance, consult a veterinarian experienced in FIP treatment.